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Image Search Results
Journal: BMC Cancer
Article Title: Subtyping atypical eosinophilic renal cell tumours through integrated morphological, immunohistochemical, and mutational characters
doi: 10.1186/s12885-026-15870-1
Figure Lengend Snippet: Histopathological and immunohistochemical features of atypical eosinophilic renal cell tumours. A1–A6: Renal oncocytoma. A1: The tumour is well-circumscribed from the surrounding tissue and unencapsulated. A2: The tumour exhibits solid and nested/sheet-like growth with intervening edematous stroma. A3: CK7 demonstrates focal strong cytoplasmic positive. A4: CD117 shows diffuse weak cytoplasmic positive. A5: CK20 is negative. A6: Colloidal iron staining is negative. B1–B6: Eosinophilic chromophobe renal cell carcinoma. B1: The tumour is relatively well-circumscribed, without involvement of the renal sinus fat. B2: Solidly packed tumour cells include distinct populations with botryoid morphology and eosinophilic cytoplasm. B3: CK7 shows diffuse strong cytoplasmic positive. B4: CD117 shows diffuse strong cytoplasmic positive. B5: CK20 is negative. B6: Colloidal iron staining is positive. C1–C6: Low-grade oncocytic tumour. C1: The tumour is well-circumscribed and unencapsulated. C2: Solid and acinar growth patterns are observed. C3: CK7 shows diffuse strong cytoplasmic positive. C4: CD117 is negative. C5: CK20 is negative. C6: Colloidal iron staining is negative. D1–D6: Eosinophilic vacuolated tumour. D1: The tumour is relatively well-circumscribed from the adjacent normal tissue, with scattered proliferative blood vessels within the tumour. D2: The tumour is arranged in solid nests and cords. D3: CK7 shows focal weak cytoplasmic positive. D4: CD117 shows diffuse moderate cytoplasmic positive. D5: CK20 is negative. D6: Colloidal iron staining is negative. E1–E6: Eosinophilic solid and cystic renal cell carcinoma. E1: The tumour is well-circumscribed, unencapsulated, and exhibits a cystic and solid structure. E2: The tumour shows cystic and solid growth patterns. E3: CK7 is negative. E4: CD117 is negative. E5: CK20 shows focal strong cytoplasmic positive. E6: Colloidal iron staining is negative. F1–F6: Normal renal tissue (Control). F1: Normal renal tissue, showing renal tubules, glomeruli, and thick-walled vessels. F2: Normal renal parenchyma. F3: CK7 shows diffuse strong cytoplasmic positive. F4: CD117 shows diffuse strong cytoplasmic positive. D5: CK20 is negative. F6: Colloidal iron staining is negative. Hematoxylin and eosin (H&E) staining x20 (A1-F1) and x40 (A2-F2). EnVision for CK7, CD117 and CK20 × 200. Colloidal iron staining x200
Article Snippet: The antibodies used in the study are CK7 (EP16, Origene, Wuxi, China), CK20 (EP23, Origene, Wuxi, China),
Techniques: Immunohistochemical staining, Staining, Control